GraphROC and Refstat - tools for clinical test evaluation and reference limits validation

GraphROC
for Windows
tools for clinical test evaluation

GraphROC for Windows is a program for estimating clinical characteristics of laboratory tests. Special attention has been paid to rapid and accurate management of frequency distributions to facilitate calculations on large data sets obtained from clinical laboratory databases. The program is well suited for clinical research. Because of the illustrative display, it can also be used for presentation of data and for teaching purposes.

Program description (version 1.0, 1995) was published by Veli Kairisto and Allan Poola in Scand. J. Clin. Lab. Invest. 1995; 55(Suppl. 222):43-60.

GraphROC

Refstat
for Windows
reference limits verifier

Most clinical laboratories depend on reference limits produced in other laboratories. It is customary that the validity of the "borrowed" reference intervals is checked by analyzing a small number of samples from healthy individuals. There is an apparent need for a powerful statistical method to extract as much information as possible from these samples.

With increased capacity of computers computing intensive statistical methods have become a practical choice for treatment and estimation of data. Holmes et al. (Clin Chem 1994;40:2216-2222) presented a method based on Monte Carlo simulation sampling technique for the verification of reference intervals. Refstat for Windows applies the method suggested by them.

Refstat